The specific form of histone proteins is what enables them to do their work. Histones 3 and 4 are well contained within specific three-dimensional forms with a precise distribution of positive electrical charges around their outer part.
It is the specific form of histone proteins that enables them to do their job. Histones 3 and 4 are well contained within specific three-dimensional forms with a precise distribution of positive electrical charges around their outer part. This precise form, with the distribution of the charge, allows the DNA to effectively wrap around the nucleosomes, and stores a huge amount of information in a very small area.16 Thanks to this nucleosome rewind, among other factors, there is a greater density of information.
To visualize how this works, imagine a large wooden bollard with grooves on its surface, then visualize the grooves of two-stranded spirals, then visualize the winding of the rope around the bollard so that it settles completely in the hollow grooves of the bollard, and finally visualize that the grooves are hollow in a way that perfectly matches the shape of the coiled rope, so that the thicker parts of the bollards are distributed in deeper grooves and the finer parts in less deep grooves.
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Source: Published on Facebook's "Braheen Center" page