Why Self-Organization Theories Fail to Explain the Origin of the Genetic Code

Self-regulation theories have failed to explain the origin of genetic code for a number of reasons. First, to explain the origin of genetic code, scientists need to explain the origin of the set of precise conformations between the trinucleotides identified in DNA (or the mRNA) and the specific amino acids (portable on tRNA), and molecular biologists have so far failed to find any significant chemical interaction between mRNAs. Instead the mRNA motif does not bind directly to the amino acid, but rather binds to the amino acid triad corresponding to the tRNA molecule, the opposite trimester and amino acid are located at the opposite ends of the tRNA and do not react chemically in any direct way, and although the amino acid reacts chemically with the nucleotide triad at the receiving end of the tRNA molecule. In all 20 tRNA molecules associated with the same nucleotide sequence, the properties of the nucleotide sequence do not determine which amino acids bind and which will not bind, and they do not care what amino acid binds to them (just as the sugar-phosphate structure in DNA does not care about which nucleotide base it binds to), the 20th triads are all accepted and no preference is given to one over the other. Thus, the chemical affinity between the nucleotide and amino acid codes does not determine the compatibility between the codes and the amino acids that determine the genetic code, and for the properties of the constituent components of the code, the code is arbitrary physically and chemically; all possible codes are equally likely, and no preference is given to one over another chemically. - Dr. Steven Meyer. — Source: Published on Facebook's "Braheen Center" page